Imidazothiazolemethylene-acetohydrazide derivatives, preparation thereof and pharmaceutical composition having diuretic activity.,申请号EP19850106521-传众专利搜索

Imidazothiazolemethylene-acetohydrazide derivatives, preparation thereof and pharmaceutical composition having diuretic activity.

申请公布号：EP0164635(A2)

申请号：EP19850106521

申请日期：1985.05.28

申请公布日期：1985.12.18

申请人：

MEDIOLANUM FARMACEUTICI S.R.L.

发明人：ANDREANI, ALDO;MASCELLANI, GIUSEPPE;RAMBALDI, MIRELLA;RUGARLI, PIERLUIGI

分类号：C07D513/04

主分类号：C07D513/04

摘要：<p>Compounds of formula I <CHEM> wherein X, Y, n, R1, R2, R3 may have the following meanings, in all the possible combinations: X and Y, which may be the same or different, represent H, CH3, C1-C6 alkyl groups, optionally substituted, aryl groups; n is 0, 1, 2; R1 represents Cl, F, Br, C1-C6 alkyl groups, aryl and alkylaryl groups optionally substituted; R2 and R3, which may be the same or different represent H, CH3, alkyl groups, cycloalkyl groups, aryl-alkyl groups containing heteroatoms, heterocyclic groups optionally benzocondensed; prepared from substituted amino-acetohydrazides and imidazo (2,1-b)-thiazole-5-carboxyaldehydes, have remarkable diuretic and antihypertensive activities.</p>