Cardenolide glucuronic acid derivs. - have positive inotropic cardiac activity similar to digoxin and digitoxin, suitable for treating cardiac insufficiency,申请号DE19772707264-传众专利搜索

Cardenolide glucuronic acid derivs. - have positive inotropic cardiac activity similar to digoxin and digitoxin, suitable for treating cardiac insufficiency

申请公布号：DE2707264(A1)

申请号：DE19772707264

申请日期：1977.02.19

申请公布日期：1978.08.24

申请人：

BEIERSDORF AG

发明人：PETERSEN,RUDOLF,DR.RER.NAT.

分类号：C07J19/00;C07J51/00;(IPC1-7):07J17/00;61K31/705

主分类号：C07J19/00

摘要：<p>Cardenolide glucuronic acids of formula (I) and their physiologically acceptable salts are new: (where R is H or OH; and n is 0, 1, 2 or 3). (I) are digitoxigenin and digoxigenin derivs. which have positive-inotropic cardiac activity of the same order of that of Digoxin and Digoxin. (I) have a similar good receptor affinity and are suitable for treatment of cardiac insufficiency. (I) have a greater rate of elimination than Digitoxin so that dangers of accumulation and the associated toxic side-effects are reduced. (I) can also be used in radioimmunology to determine the influence of cardenolide glucoronides on cardenolide concns. in the blood.</p>