STIMULUS-INDUCIBLE I (KAPPA)B KINASE IKK SIGNALSOME

申请公布号：EP0920518(A1)

申请号：EP19970938616

申请日期：1997.08.26

申请公布日期：1999.06.09

申请人：

SIGNAL PHARMACEUTICALS, INC.

发明人：MERCURIO, FRANK;ZHU, HENGYI;BARBOSA, MIGUEL;LI, JIAN WU;MURRAY, BRION, W.

分类号：G01N33/50;A61K38/00;A61K39/395;A61K45/00;A61K48/00;A61P43/00;C07K14/47;C07K16/40;C12N1/19;C12N1/21;C12N5/10;C12N9/12;C12N15/09;C12N15/54;C12P21/08;C12Q1/48;G01N33/15;G01N33/573

主分类号：G01N33/50

摘要：Compositions and methods are provided for treating NF-kappaB-related conditions. In particular, the invention provides a stimulus-inducible IKK signalsome, and components and variants thereof. An IKK signalsome or component thereof may be used, for example, to identify antibodies and other modulating agents that inhibit or activate signal transduction via the NF-kappaB cascade. IKK signalsome, components thereof and/or modulating agents may also be used for the treatment of diseases associated with NF-kappaB activation.

Liquid embolic material including carboxymethyl chitosan crosslinked with carboxymethyl cellulose

Macrocyclic compounds as hepatitis C virus inhibitors

Cosmetic composition comprising at least one cationic poly(vinyllactam), at least one fatty alcohol and at least one amino silicone, cosmetic process and use of the composition

Alkylation process unit for producing high quality gasoline blending components in two modes

Blood coagulation analyzer, blood coagulation analysis method, and computer program product

Optoelectronic switches using on-chip optical waveguides

Pattern recognition apparatus and method therefor configured to recognize object and another lower-order object

Image processing apparatus, method of controlling the same, distance measurement apparatus, and storage medium

Systems and methods for secure communication using a communication encryption bios based upon a message specific identifier

Encoding apparatus, electronic device, imaging apparatus, and imaging system

Surface-emitting laser element, surface-emitting laser array, optical scanning apparatus, image forming apparatus, and method of manufacturing surface-emitting laser element

System and method for industrial control using a high availability backplane

Storage system comprising function for migrating virtual communication port added to physical communication port

Methods and apparatus to limit transmission of data to a localized area

Frequency hopping in 5GHz WLAN via dynamic frequency selection

System and method for connecting, configuring and testing wireless devices and applications

Wireless router systems and methods

Handoff of a mobile station between packet-switched and circuit-switched wireless domains

Carrying case with multi-frequency shielding

Flow diversion apparatuses and methods