STABLE PHARMACEUTICAL COMPOSITION OF BDNF

申请公布号：WO1997045135(A1)

申请号：JP1997001746

申请日期：1997.05.26

申请公布日期：1997.12.04

摘要：<p>A stable pharmaceutical composition of brain derived neurotrophic factor (BDNF) in the form of an aqueous solution or lyophilized one being suitable for a long-term storage, which contains a surfactant, especially nonionic surfactant (e.g., Tween 80) of 0.001 to 10 %, whereby the polymerization and the denaturation of BDNF are inhibited, and the biological activities of BDNF are maintained for a long time. Said lyophilized composition can be made more stable by addition of a sugar alcohol (e.g., mannitol) and/or an amino acid (e.g., glycine).</p>

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