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Controlled release potassium chloride

申请公布号:US4863743(A)

申请号:US19860830981

申请日期:1986.02.19

申请公布日期:1989.09.05

申请人:
KEY PHARMACEUTICALS, INC.

发明人:HSIAO, CHARLES;CHOU, CHI T.

分类号:A61K9/20;A61K9/22;A61K9/50;A61K33/14

主分类号:A61K9/20

摘要:A controlled release potassium chloride tablet is disclosed which is comprised of potassium chloride crystals having a mesh size of about 30 to about 50 mesh which are coated with a coating material comprised of ethylcellulose and hydroxypropylcellulose. The coated crystals form micro pellets which then can be compressed into tablets. The tablets disintegrate rapidly in an aqueous environment thus assuring a more uniform dissolution of the active component as compared with other types of controlled release potassium chloride dosage formulations. The distribution of the potassium chloride micro pellets over a wide surface area in the gastrointestinal mucosa aids in reducing the risk of gastrointestinal lesions. The formation of the coated micro pellets which disperse quickly upon contact with aqueous environment allow for the repeated chronic oral administration of a relatively large dose of potassium chloride (20 mEq).

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