GENE NECESSARY FOR STRIATAL FUNCTION AND USES THEREOF, AND COMPOUNDS FOR MODULATING SAME,申请号CA20002320400-传众专利搜索

GENE NECESSARY FOR STRIATAL FUNCTION AND USES THEREOF, AND COMPOUNDS FOR MODULATING SAME

申请公布号：CA2320400(A1)

申请号：CA20002320400

申请日期：2000.10.06

申请公布日期：2001.04.07

申请人：

NOVANEURON INC.

发明人：DENOVAN-WRIGHT, EILEEN M.;ROBERTSON, HAROLD A.

分类号：A61K31/495;A61K31/65;A61K31/7088;A61K45/06;A61K48/00;C12Q1/00;C12Q1/68;(IPC1-7):A61K31/708

主分类号：A61K31/495

摘要：PDE10A, a gene that is normally highly expressed in mammalian striatum and elsewhere, has been found to decrease in expression during the development of CAG repeat disorders such as Huntington's disease. The invention teaches a method for detecting the presence of or the predisposition for a CAG repeat disorder. Compounds which modulate CAG repea t disorders and their uses are taught. Methods for screening for further compounds to modulate CAG repeat disorders are also taught.