2-acyloxy-4-morpholinyl anthracyclines,申请号US19930987281-传众专利搜索

2-acyloxy-4-morpholinyl anthracyclines

申请公布号：US5510469(A)

申请号：US19930987281

申请日期：1993.05.12

申请公布日期：1996.04.23

申请人：

FARMITALIA CARLO ERBQ S.R.L.

发明人：FAIARDI, DANIELA;BARGIOTTI, ALBERTO;SUARATO, ANTONINO

分类号：A61K31/70;A61K31/7028;A61K31/7034;A61K31/704;A61K31/7042;A61K31/7052;A61P35/00;C07H15/252;C07H19/24;(IPC1-7):C07H15/24

主分类号：A61K31/70

摘要：PCT No. PCT/EP91/01506 Sec. 371 Date May 12, 1993 Sec. 102(e) Date May 12, 1993 PCT Filed Aug. 8, 1991 PCT Pub. No. WO92/04362 PCT Pub. Date Mar. 19, 1992.Anthracycline glycosides of formula 1: <IMAGE> 1 wherein R1 is hydrogen or methoxy group; R2 is hydrogen or hydroxy; both R3 and R4 represent hydrogen or one of R3 and R4 is hydroxy and the other of R3 and R4 a represents hydrogen; R5 represents hydrogen atom or an acyl residue-COX in which X is a C1-C8 linear or branched alkyl chain, an aryl, an aryl lower alkyl, or a 5- or 6-membered heteroaromatic group are anti-tumour agents.