ALKYLIDENE ANALOGS OF 1'-AMINOSPIRO-[ISOQUINOLINE- 4(1H),3'-PYRROLIDINE]-1,2',3,5'(2H)-TETRONES USEFUL AS ALDOSE REDUCTASE INHIBITORS IN VIVO,申请号GR19990400972T-传众专利搜索

ALKYLIDENE ANALOGS OF 1'-AMINOSPIRO-[ISOQUINOLINE- 4(1H),3'-PYRROLIDINE]-1,2',3,5'(2H)-TETRONES USEFUL AS ALDOSE REDUCTASE INHIBITORS IN VIVO

申请公布号：GR3029883(T3)

申请号：GR19990400972T

申请日期：1999.04.05

申请公布日期：1999.07.30

申请人：

AMERICAN HOME PRODUCTS CORPORATION

发明人：MALAMAS, MICHAEL, SOTIRIOS

分类号：A61K31/47;A61K31/4747;A61P3/00;A61P7/00;A61P13/02;A61P13/12;A61P15/00;A61P25/00;A61P27/02;A61P27/12;A61P43/00;C07D471/10;C12N9/99;(IPC1-7):C07D471/10

主分类号：A61K31/47

摘要：<p>This invention relates to alkylidene analogs of 1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones, represented by formula (I): <IMAGE> (I) to processes for the preparation, to methods for using the compounds, and to pharmaceutical preparations thereof. The compounds have pharmaceutical properties which render them beneficial for the prevention or treatment of diabetes mellitus associated complications.</p>