THE ST-B17 SEROTONIN RECEPTOR,申请号CA19932147839-传众专利搜索

THE ST-B17 SEROTONIN RECEPTOR

申请公布号：CA2147839(A1)

申请号：CA19932147839

申请日期：1993.10.26

申请公布日期：1994.05.11

申请人：

GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (THE)

发明人：SIBLEY, DAVID R.;MONSMA, FREDERICK J., JR.;HAMBLIN, MARK W.

分类号：C07K14/705;C12N15/12;C12P21/08;(IPC1-7):C12N15/12;C12Q1/02;C12N5/10;C07K16/28;G01N33/566;C12Q1/68

主分类号：C07K14/705

摘要：Genes encoding the St-B17 serotonin receptor protein were cloned and characterized from a rat striatum mRNA and a human genomic library. The St-B17 receptor has nucleotide and amino acid homology with previously described 5-HT genes and can bind ligands that are known to interact with serotonin receptors. In addition, the levels of intracellular cAMP in cells transfected with the receptor gene respond in a dose dependent manner to introduction of serotonin in the media.