Deuterated CFTR potentiators

申请公布号：US9512079(B2)

申请号：US201514921158

申请日期：2015.10.23

申请公布日期：2016.12.06

申请人：

Concert Pharmaceuticals, Inc.

发明人：Morgan Adam J.

分类号：A61K31/44;C07D215/56

主分类号：A61K31/44

代理机构：

McCarter & English, LLP

代理人：McCarter & English, LLP ;Davis Steven G.;Dertz Emily

地址：Lexington MA US

摘要：This invention relates to compounds of Formula I:; and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a CFTR potentiator.

主权项：1. A compound represented by the formula:or a pharmaceutically acceptable salt thereof, wherein any atom not designated as deuterium is present at its natural isotopic abundance, and wherein the deuterium incorporation at each designated deuterium atom is at least 90%.

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