VERFAHREN ZUR HERSTELLUNG VON SUBSTITUIERTEN CHROMANDERIVATEN,申请号AT19990124191T-传众专利搜索

VERFAHREN ZUR HERSTELLUNG VON SUBSTITUIERTEN CHROMANDERIVATEN

申请公布号：AT222249(T)

申请号：AT19990124191T

申请日期：1999.12.03

申请公布日期：2002.08.15

申请人：

BASF AKTIENGESELLSCHAFT

发明人：STUERMER, RAINER, DR.;BALDENIUS, KAI-UWE, DR.

分类号：C07D309/30;C07D311/66;C07D311/70;C07D407/04;(IPC1-7):C07D311/70;C07D311/74

主分类号：C07D309/30

摘要：<p>Preparation of substituted chroman derivatives in multi-stage process from acrolein-aldehyde starting material via new intermediates. Preparation of substituted chroman derivatives of formula (VII) comprises: (a) reacting an acrolein-aldehyde of formula (I) with an acrylonitrile-, acrolein-, acrolein-acetal-, allyl-alcohol- or allyl ether of formula (II) to give the corresponding 3,4-dihydro-2H-pyran of formula (III); (b) treating (III) with an acid to give the corresponding 5-oxo derivative of formula (IV); (c) reacting this with a substituted vinyl-ketone of formula (V) to give a chromen-6-one of formula (VI); and (d) dehydrating to give (VII). X = CN, COOR3, CHO, CH2OR7 or CH(OR8)2; R1 = 1-4C alkyl, 6-18C aryl, 7-18C aralkyl, optionally halogenated 1-4C acyl or an acid labile hydroxy protecting group; R2 = 1-23C alkyl, 2-23C alkenyl, 6-18C aryl or 7-18C aralkyl; R3 = H, 1-4C alkyl, 1-4C haloalkyl, 1-4C hydroxyalkyl or 1-4C aminoalkyl; R4-R6 = H or 1-4C alkyl; R7 = H or 1-4C alkyl; R8 = 1-4C alkyl; or R8+R8 = 2-6C alkenyl optionally branched and optionally substituted by 1-2 carboxyl, cyclohexyl or phenyl. Independent claims are included for: (1) pyran derivatives (III) as new; (2) preparation of (III) using step (a) as above; (3) tetrahydropyran derivatives (IV); (4) preparation of (IV) using steps (a) and (b) as above; (5) chromen-6-one derivatives (VI); (6) preparation of (VI) using step (c) as above.</p>