NEW TRIAZOLE DERIVATIVE AND ANTIFUNGAL AGENT HAVING THE SAME AS ACTIVE INGREDIENT,申请号JP20030021286-传众专利搜索

NEW TRIAZOLE DERIVATIVE AND ANTIFUNGAL AGENT HAVING THE SAME AS ACTIVE INGREDIENT

申请公布号：JP2006151812(A)

申请号：JP20030021286

申请日期：2003.01.30

申请公布日期：2006.06.15

申请人：

MEIJI SEIKA KAISHA LTD

发明人：UMEMURA EIJIRO;SASAKI KAZUE;SEITSU FUMIHITO;TADAUCHI KAORI;OKUTOMI TAKAFUMI

分类号：C07D513/04;A61K31/429;A61P31/10;C07D521/00

主分类号：C07D513/04

摘要：PROBLEM TO BE SOLVED: To provide a new triazole derivative which has a potent antifungal effect on both Candida and Aspergillus in treating deep mycosis of a problem in recent years and is effective against furconazole-resistant Candida albicans. SOLUTION: The new triazole derivative is represented by formula (I) (wherein n is an integer of 0 or 1; R<SP>1</SP>is hydrogen or a lower alkyl; and any one of R<SP>2</SP>and R<SP>4</SP>may be linked with CO and the remaining one may be the same or different from R<SP>3</SP>, and are each hydrogen, a halogen, a substituted or nonsubstituted phenyl group or the like or R<SP>2</SP>and R<SP>3</SP>are linked with each other to form a substituted or nonsubstituted benzene ring, cyclopentene ring or cyclohexene ring) or its pharmacologically acceptable salt. An antifungal agent is composed of these triazole derivatives. A pharmaceutical composition contains these triazole derivatives as active ingredients. COPYRIGHT: (C)2006,JPO&NCIPI