SUSTAINED-RELEASE PHARMACEUTICAL COMPOSITION,申请号EP20110832614-传众专利搜索

SUSTAINED-RELEASE PHARMACEUTICAL COMPOSITION

申请公布号：EP2628488(A4)

申请号：EP20110832614

申请日期：2011.10.14

申请公布日期：2016.07.27

申请人：

KYOTO UNIVERSITY;KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION;KAKEN PHARMACEUTICAL CO., LTD.;KOKEN CO., LTD.

发明人：FUKUSHIMA, MASANORI;MATSUBARA, HIROAKI;MATOBA, SATOAKI;HIJIKATA, SHIGEKI;ASO, YU;SATO, TSUTOMU

分类号：A61K47/42;A61K9/00;A61K9/08;A61K9/51;A61K31/7004;A61K31/7008;A61K38/00;A61K38/18;A61K38/27;A61K38/39;A61K45/00;A61K45/06;A61K47/26;A61K47/36;A61P1/02;A61P9/00;A61P9/10;A61P17/02;A61P19/00;A61P35/00;A61P43/00

主分类号：A61K47/42

摘要：Provided is a pharmaceutical composition, including a drug and a collagen, in which the composition is satisfactory in handleability and has sustained-release property. The sustained-release pharmaceutical composition includes: a drug; a collagen; and at least one kind of sugar selected frommonosaccharides, disaccharides, trisaccharides, and tetrasaccharides. The inventors of the present invention have found that the in vivo administration of a collagen solution containing a sugar results in the gelation of a collagen. Based on this finding, the inventors have found that a composition containing a drug, a collagen, and a sugar can control the release rate of the drug, and such composition can be used as a sustained-release pharmaceutical composition.