INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1,申请号WO2007US67350-传众专利搜索

INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1

申请公布号：WO2007127763(A3)

申请号：WO2007US67350

申请日期：2007.04.25

申请公布日期：2007.12.13

申请人：

ELI LILLY AND COMPANY;WINNEROSKI, LARRY, LEONARD, JR.;MABRY, THOMAS, EDWARD;SNYDER, NANCY, JUNE;WALLACE, OWEN, BRENDAN;XU, YANPING

发明人：WINNEROSKI, LARRY, LEONARD, JR.;MABRY, THOMAS, EDWARD;SNYDER, NANCY, JUNE;WALLACE, OWEN, BRENDAN;XU, YANPING

分类号：C07D209/44;A61K31/4015;A61P3/10;C07D401/10;C07D403/10;C07D487/10

主分类号：C07D209/44

摘要：The present invention discloses novel compounds of Formula (I): having 11ß-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as methods of using the compounds and compositions to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, metabolic syndrome, and other conditions associated with 11ß-HSD type 1 activity.