METHOD FOR SCREENING NOX4 INHIBITOR OR SUPPRESSOR AND UTILIZATION THEREOF,申请号JP20060222753-传众专利搜索

METHOD FOR SCREENING NOX4 INHIBITOR OR SUPPRESSOR AND UTILIZATION THEREOF

申请公布号：JP2008022841(A)

申请号：JP20060222753

申请日期：2006.07.24

申请公布日期：2008.02.07

申请人：

PREV PHARMA:KK;SHINSHU UNIV

发明人：KAMATA TORU

分类号：C12Q1/48;A61K45/00;A61P35/00;A61P43/00;C12N9/99;C12N15/09;G01N33/15;G01N33/50;G01N33/574

主分类号：C12Q1/48

摘要：PROBLEM TO BE SOLVED: To provide a method for screening a Nox4 inhibitor or suppressor having a high efficacy from Nox4 inhibitor or suppressor candidates, and to provide a pharmaceutical composition for treating cancers such as pancreatic cancer, melanoma and glioma (cerebral tumor), containing the Nox4 inhibitor or suppressor having the high efficacy and screened by the method. SOLUTION: This method for screening the Nox4 inhibitor or suppressor comprises effectively searching the effective Nox4 inhibitor or suppressor from candidate substances, while using a signal transduction to AKT/ASK1 as an indicator. The Nox4 inhibitor or suppressor searched by the screening method can suppress the proliferation of cancer tissue cells including living pancreatic cancer, melanoma and glioma. COPYRIGHT: (C)2008,JPO&INPIT