1-Indolylalkyl-4-(substituted-pyridinyl)piperazines.

申请公布号：EP0345808(A1)

申请号：EP19890110485

申请日期：1989.06.09

申请公布日期：1989.12.13

申请人：

BRISTOL-MYERS COMPANY

发明人：SMITH, DAVID WILLIAM;YOCCA, FRANK D.;YEVICH, JOSEPH PAUL;MATTSON, RONALD JOHN

分类号：C07D487/04;A61K31/44;A61K31/495;A61P25/24;A61P25/26;C07D401/12;C07D401/14;C07D487/08

主分类号：C07D487/04

摘要：A compound of Formula I and the pharmaceutically acceptable acid addition salts thereof, <CHEM> wherein R<1> and R<2> are independently selected from lower, meaning C1-4, alkyl or hydrogen; R<3>, R<4>, R<8> and R<9> are independently selected from hydrogen, lower alkyl, lower alkoxy, carbamide, halogen, trifluoromethyl and thio-lower alkyl, with the proviso that R<8> and R<9> cannot both be hydrogen at the same time; A is a C5-7 cycloalkanyl or cycloalkenyl ring, or A is <CHEM> wherein n is an integer from 1 to 3 and R<5> is the same as R<1>; and R<6> and R<7> are independently selected from hydrogen, methyl or R<6> and R<7> can be taken together as a methylene bridge, useful as antidepressants.