LONG-ACTING GROWTH HORMONE AND METHODS OF PRODUCING SAME.

申请公布号：MX2014001335(A)

申请号：MX20140001335

申请日期：2012.08.02

申请公布日期：2016.09.26

申请人：

OPKO BIOLOGICS LTD.

发明人：Udi Eyal FIMA;Fuad FARES

分类号：A61K38/27

主分类号：A61K38/27

摘要：Use of a growth hormone protein and polynucleotides encoding same comprising an amino-terminal carboxy-terminal peptide (CTP) of chorionic gonadotrophin and two carboxy-terminal chorionic gonadotrophin CTPs attached to the growth hormone in methods of inducing weight loss or body fat reduction, methods of increasing insulin-like growth factor (IGF-1) levels, and methods of reducing the dosing frequency of a growth hormone in a human subject are disclosed. Pharmaceutical compositions comprising the growth hormone and polynucleotides encoding the growth hormone of the invention and methods of using same are also disclosed.

THERMOSTAT APPARATUS

UN METODO Y UN APARATO PARA LA PRODUCCION Y ENVASADO DE SALCHICHAS SIN PIEL

FREMGANGSMADE TIL VED VAND ELLER DAMPKOGNING AT TILBEREDE LEVNEDSMIDLER SAMT ANORDNING TIL UDOVELSE AF FREMGANGSMADEN

SPREADER FOR FINE DUST

METHOD OF MANUFACTURING SHEETTLIKE MATERIAL FOR ROAD REPAIRING

FLUID MIXER

IMIDAZOLE DERIVATIVES

DECODER

TV RECEIVER

SOUND INSULATION WALL AND ITS CONSTITUTION METHOD

TWO TANKS WASHING MACHINE

Elastic thermal insulation for low temp. containers - with individual sheets joined by elastic insulation in sandwich construction

Fireproof trap door with insulating frame - has insulation retained inside tray of trap door and insulation inside frame

PROCEDE POUR LA FABRICATION D'ELEMENTS GALVANIQUES AVEC DES ELECTRODES NEGATIVES DE LITHIUM OU DE CALCIUM

COMPOSICION PLAGUICIDA DE DISPENSACION GRADUAL DE PH3 Y PROCEDIMIENTO PARA PREPARARLA

ESTRUCTURA MODULAR DESMONTABLE PARA ESTANTERIAS Y OTROS USOS

UN SONAJERO

DISPOSICION PARA SELECCIONAR EN FORMA ALEATORIA UN DISPOSITIVO ENTRE UN A PLURALIDAD DE DISPOSITIVOS SELECCIONABLES,DE UN SISTEMA DE TELECOMUNICACION

UN APARATO DE SEPARACION DE UNA MEZCLA DE GRANOS DE MINERAL CON DIFERENTES PESOS ESPECIFICOS

DISPOSICION INVIOLABLE DE FIJACION DE TAPAS PARA CAJA Y BORNERA DE APARATOS CONTADORES O MEDIDORES DE VATIOS O ELEMENTOS DE CONEXIONES QUE DEBAN PROTEGERSE