Lingo-2 antagonists for treatment of conditions involving motor neurons

申请公布号：NZ702178(A)

申请号：NZ20130702178

申请日期：2013.05.14

申请公布日期：2017.01.27

申请人：

Biogen MA Inc.

发明人：Mi Sha;Pepinsky R. Blake

分类号：A61K39/395

主分类号：A61K39/395

摘要：The invention provides methods of treating diseases, disorders or injuries involving motor neuron survival and axonal growth, including amylotrophic lateral sclerosis, by the administration of a LINGO-2 antagonist. An exemplary method for promoting survival of a motor neuron, comprising contacting said motor neuron with an effective amount of a composition comprising a LINGO-2 antagonist selected from the group consisting of: (i) a soluble LINGO-2 polypeptide; (ii) a LINGO-2 antibody or antigen-binding fragment thereof; (iii) a LINGO-2 antagonist polynucleotide; (iv) a LINGO-2 aptamer; and (v) a combination of two or more of said LINGO-2 antagonists.

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