BIOSENSORS COMPRISING CONCATEMERIC NUCLEIC ACID MOLECULES,申请号US201615079418-传众专利搜索

BIOSENSORS COMPRISING CONCATEMERIC NUCLEIC ACID MOLECULES

申请公布号：US2016281145(A1)

申请号：US201615079418

申请日期：2016.03.24

申请公布日期：2016.09.29

申请人：

McMaster University

发明人：Brennan John D.;Li Yingfu;Carrasquilla Carmen

分类号：C12Q1/68;G01N33/53

主分类号：C12Q1/68

地址：Hamilton CA

摘要：The present application relates to biosensors, for example comprising an high-molecular weight, tandem repeating, structure-switching nucleic acid aptamers (concatemeric aptamers) to rapidly create patterned sensors via, for example, inkjet printing. These concatemeric aptamer reporters remain immobilized at the point of printing through strong adsorption but retain sufficient segmental mobility to undergo structure switching and reporter signalling to provide both qualitative and quantitative detection of one or more analytes. In certain embodiments, inkjet printing allows for the patterning of internally referenced sensors with multiplexed detection, and provides a generic platform for on-demand printing of sensors even in remote locations.

主权项：1. A biosensor for detecting an analyte comprising: a) a substrate; and b) one or more reporter layers absorbed on the substrate, each of the one or more reporter layers comprising one or more concatemeric nucleic acid molecules and one or more reporter nucleic acid molecules for detection of the analyte, wherein the one or more reporter layer is absorbed on the substrate by non-chemical means selected from printing and spotting.