METHOD OF TROVENTOL PRODUCING,申请号RU20140152556-传众专利搜索

METHOD OF TROVENTOL PRODUCING

申请公布号：RU2593333(C2)

申请号：RU20140152556

申请日期：2014.12.24

申请公布日期：2016.08.10

申请人：

Zakrytoe aktsionernoe obshshestvo "Aktivnyj Komponent"

发明人：SHklyarenko Artem Aleksandrovich;Logvinov Aleksandr Vladimirovich;Korchevskaya Elena Vladimirovna;Bulatova Anna Vadimovna

分类号：A61K31/46;C07B33/00;C07B63/00

主分类号：A61K31/46

摘要：FIELD: pharmaceutics.SUBSTANCE: described is method of producing troventol, which consists in oxymethylation of tropine ether of 2-phenyl-butyric acid in dimethylacetamide solution in presence of potassium tert-butylate. Then one performs extraction of by-products with ethyl acetate, or toluene, or heptane, depositing tropine ether of 2-hydroxymethyl-2-phenyl-butyric acid with alkali metal carbonate with subsequent recrystallisation from acetonitrile and quaternization in acetonitrile solution. Further, troventol crystals are separated. Invention provides easy-to-implement and suitable for industrial use method of producing troventol with purity exceeding 99.5 %.EFFECT: simple method of producing troventol with high purity.5 cl, 5 dwg, 5 ex