アセチレン誘導体及びその医薬用途,申请号JP20120551051-传众专利搜索

アセチレン誘導体及びその医薬用途

申请公布号：JP5931744(B2)

申请号：JP20120551051

申请日期：2011.12.28

申请公布日期：2016.06.08

申请人：

キッセイ薬品工業株式会社

发明人：滝川靖;恩田雄介;清水和夫

分类号：C07C255/57;A61K31/277;A61K31/381;A61K31/426;A61K31/427;A61K31/4418;A61P13/04;A61P13/12;A61P19/02;A61P19/06;A61P29/00;A61P43/00;C07D213/79;C07D277/56;C07D333/38;C07D333/40;C07D417/04

主分类号：C07C255/57

摘要：A novel compound with a uric acid generation inhibiting action is provided. The present invention pertains to an acetylene derivative indicated in formula (I), a prodrug thereof, or a salt of same, that has a xanthine oxidase inhibitory activity and is useful as a prophylactic or therapeutic agent for diseases caused by an abnormal serum urate level. In formula (I): R1 is a hydrogen atom, a C1-6 alkyl, or a C3-8 cycloalkyl, etc.; M is a C6-10 aryl or 5- or 6-membered cyclic heteroaryl; Q is carboxy, etc.; Y independently represents a hydroxyl group or a C1-12 alkyl, etc.; and n is 1 or 2. The group represented by -W-M is a group etc., represented by formula (A), wherein: T is cyano, etc.; and R2 is a hydrogen atom, a fluorine atom, a C1-6 alkyl, or a C1-6 alkoxy, etc.