SELF-RETAINING SUTURES OF POLY-4-HYDROXYBUTYRATE AND COPOLYMERS THEREOF,申请号WO2015US44280-传众专利搜索

SELF-RETAINING SUTURES OF POLY-4-HYDROXYBUTYRATE AND COPOLYMERS THEREOF

申请公布号：WO2016025329(A1)

申请号：WO2015US44280

申请日期：2015.08.07

申请公布日期：2016.02.18

申请人：

TEPHA, INC.

发明人：RIZK, SAID;WILLIAMS, SIMON, F.

分类号：A61L27/18;A61L17/10;A61L31/06

主分类号：A61L27/18

摘要：Absorbable monofilament fibers and self-retaining sutures with high tensile strengths have been developed. The straight pull tensile strengths of the absorbable self-retaining sutures closely approximate, equal or exceed the average minimum knot-pull tensile standards set by the United States Pharmacopeia (USP). These higher strength absorbable self-retaining sutures can therefore be used either without needing to oversize the suture for a given procedure, or by oversizing the self-retaining suture by no more than 0.1 mm in diameter. In one embodiment, the absorbable self-retaining sutures are made from poly-4-hydroxybutyrate or copolymers thereof. Methods for producing absorbable self-retaining sutures that have high tensile strengths and pronounced sheath-core structures wherein the sheath is harder than the core are also provided. The self-retaining sutures may be made by spinning and orienting a monofilament fiber of poly-4- hydroxybutyrate or copolymer thereof and inserting retainers in monofilament fibers.