PHENYL C-GLUCOSIDE DERIVATIVE CONTAINING DEOXYGLUCOSE STRUCTURE, PREPARATION METHOD AND USE THEREOF,申请号US201314652225-传众专利搜索

PHENYL C-GLUCOSIDE DERIVATIVE CONTAINING DEOXYGLUCOSE STRUCTURE, PREPARATION METHOD AND USE THEREOF

申请公布号：US2016046595(A1)

申请号：US201314652225

申请日期：2013.12.05

申请公布日期：2016.02.18

申请人：

TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH

发明人：Zhao Guilong;Wang Yuli;Liu Bingni;Xie Yafei;Liu Yuqiang;Liu Peng;Wu Jiang;Hou Jiajia;Wei Wei;Du Wen;Xu Weiren;Tang Lida;Zou Meixiang

分类号：C07D309/10;A61K47/22

主分类号：C07D309/10

地址：Tianjin CN

摘要：The present invention provides a phenyl C-glucoside derivative containing a deoxyglucose structure as represented by formula I, preparation method thereof, a pharmaceutical composition comprising the same, and uses thereof in the preparation of medicaments for treating diabetes, wherein substituents R1-R7 are as defined in the specification. The present invention also provides a method for synthesizing the phenyl C-glucoside derivative containing a deoxyglucose structure and an intermediate product. The method has advantages of being simple to manage and of low cost, which is suitable for large-scale industrial production. The present invention further provides a cocrystal of (1S)-1-[4-chloro-3-(4-ethoxybenzyl)phenyl]-1,6-dideoxy-D-glucose and L-proline, and preparation method and uses thereof.;