METHODS FOR TREATING INTERLEUKIN-1 MEDIATED DISEASES,申请号CA19912039458-传众专利搜索

METHODS FOR TREATING INTERLEUKIN-1 MEDIATED DISEASES

申请公布号：CA2039458(A1)

申请号：CA19912039458

申请日期：1991.03.28

申请公布日期：1991.10.03

申请人：

SYNERGEN, INC.

发明人：CARMICHAEL, DAVID F.;SMITH, CHRISTOPHER G.;THOMPSON, ROBERT C.

分类号：C12P21/02;A61K;A61K31/00;A61K38/00;A61K38/20;A61K39/395;A61P1/00;A61P3/00;A61P3/04;A61P3/08;A61P3/10;A61P9/00;A61P9/10;A61P11/00;A61P11/06;A61P17/00;A61P17/06;A61P19/00;A61P19/02;A61P19/10;A61P29/00;A61P31/04;A61P35/00;A61P35/02;A61P43/00;C07K14/545;C07K14/715;C07K16/24;(IPC1-7):A61K39/395

主分类号：C12P21/02

摘要：73605-14 of the Invention Disclosed are medicines for treating interleukin-1 mediated diseases including interleukin-1 mediated arthritis, interleukin-1 mediated inflammatory bowel disease, interleukin-1 mediated septic shock, interleukin-1 mediated ischemia injury, and interleukin-1 mediated reperfusion injury. The medicine comprises a therapeutically effective amount of an interleukin-1 inhibitor. In a preferred embodiment, the interleukin inhibitor is selected from the group consisting of IL-lraa, IL-lraB, IL-lrax, and a combination thereof. A preferred method of producing IL-lraa, IL-lraB, Il-lrax is by recombinant DNA technology.