APPLICATION OF ANTAGONISTS OF OPIOID RECEPTORS IN CASE OF GASTROINTESTINAL TRACT DISEASES

申请公布号：RU2561873(C2)

申请号：RU20120115450

申请日期：2010.09.17

申请公布日期：2015.09.10

申请人：

ADOLOR KORPOREJSHN

发明人：VUDVORD RICHARD M.

分类号：A61K31/497

主分类号：A61K31/497

摘要：FIELD: medicine.SUBSTANCE: group of inventions relates to medicine, namely to method of treatment or prevention of opioid-induced constipation or opioid-induced intestine dysfunction in patients without reduction of mediated opioid anaesthesia or development of symptoms of central opioid withdrawal, associated with activation of opioid receptors on periphery. For this purpose effective quantity of 5-(2-methoxy-4-{[2-(tetrahydropyran-4-yl)-ethylamino]methyl}-phenoxy)pyrazine-2-carboxamide (Compound I) or its pharmaceutically acceptable salt is introduced to patient.EFFECT: group of inventions provides treatment or prevention of frequent side effects in patients who have taken opioids for several days.12 cl, 9 dwg, 1 tbl, 3 ex

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