Paste-like bone cement,申请号US201213715314-传众专利搜索

Paste-like bone cement

申请公布号：US9018277(B2)

申请号：US201213715314

申请日期：2012.12.14

申请公布日期：2015.04.28

申请人：

Heraeus Medical GmbH

发明人：Vogt Sebastian

分类号：A61L24/04;A61K6/00;A61K6/083;A61L24/00;A61L27/16;A61L27/26;A61L27/50;A61L24/06

主分类号：A61L24/04

代理机构：

Norris McLaughlin & Marcus, P.A.

代理人：Norris McLaughlin & Marcus, P.A.

地址：Wehrheim DE

摘要：The present invention relates to a kit comprising at least two pastes, A and B. Paste A contains at least one monomer for radical polymerization; and at least one barbituric acid derivative as polymerization initiator. Paste B contains at least one monomer for radical polymerization; and at least one heavy metal compound as polymerization accelerator that is selected from heavy metal salts and heavy metal complexes. Paste B contains less than 0.01% by weight, relative to the total weight of paste B, of a peroxide; at least one of the pastes A and B contains-at least one filling agent that is poorly soluble or insoluble in the monomer for radical polymerization in either paste A or B respectively; and at least one of the pastes A and B contains at least one inorganic halide salt.

主权项：1. A kit comprising a paste A and a paste B, whereby (a) paste A comprises (a1) at least one monomer for radical polymerisation; and(a2) at least one barbituric acid derivative as polymerisation initiator; (b) paste B comprises (b1) at least one monomer for radical polymerisation; and(b2) at least one heavy metal compound as polymerisation accelerator, wherein the heavy metal compound is selected from the group consisting of copper(II) hydroxide, basic copper(II) carbonate, copper(II) chloride, copper(II) 2-ethylhexanoate or mixtures thereof; wherein i) paste B contains less than 0.01% by weight, relative to the total weight of paste B, of a peroxide; ii) at least one of the pastes A and B contains, as component (a3) and/or (b3), at least one filling agent that is insoluble or poorly soluble in (a1) and/or (b1), respectively; iii) at least one of the pastes A and B contains at least one inorganic halide salt as component (a4) and/or (b4), wherein the inorganic halide salt is selected from alkali halides, earth alkali halides, halide salts of zinc and zirconium and halide salts of zirconium oxide or mixtures thereof; iv) the barbituric acid derivative (a2) is soluble in the monomer (a1) for radical polymerisation; v) the barbituric acid derivative (a2) is selected from the group consisting of 1-mono-substituted barbiturates, 5-mono-substituted barbiturates, 1,5-di-substituted barbiturates, 1,3,5-tri-substituted barbiturates, and 1,3,5-tetra-substituted barbiturates; and vi) paste A contains 15 to 85% by weight, relative to the total weight of paste A, of a filling agent (a3) that is insoluble or poorly soluble in (a1) and paste B contains less than 5% by weight, relative to the total weight of paste B, of a filling agent (b3) that is insoluble or poorly soluble in (b1).