Psoralen-inactivated viral vaccine and method of preparation,申请号US201012838449-传众专利搜索

Psoralen-inactivated viral vaccine and method of preparation

申请公布号：US9005633(B2)

申请号：US201012838449

申请日期：2010.07.17

申请公布日期：2015.04.14

申请人：

The United States of America as Represented by the Secretary of the Navy.

发明人：Kochel Tadeusz J.;Maves Ryan C.;Porter Kevin

分类号：A61K39/12;C12N7/06;C12N7/00;A61K39/00

主分类号：A61K39/12

代理人：Yang Ning;Churilla Albert M.

地址：Washington DC US

摘要：A method to prepare inactivate viral vaccine by exposing the virus to a predetermined concentration of an inactivating psoralen, and a preselected intensity of ultraviolet radiation for a time period sufficiently long to render the virus non-infectious but less than that which would result in degradation of its antigenic characteristics.

主权项：1. A method for inactivating a live virus for use as an immunogenic composition comprising: a) exposing said virus to an inactivating psoralen, wherein said psoralen is selected from the group consisting of 4′-Aminomethyltrioxalen hydrochloride (AMT), 8-Methoxypsoralen (8-MOP), 4, 5′, 8-Trimethylpsoralen (TMP) and a combination thereof, and b) exposing said virus to a preselected intensity of an ultraviolet radiation for 5 to 30 minutes, which is sufficiently long to render the virus non-infectious but would not result in degradation of its antigenicity.