HETEROARYL INHIBITORS OF PDE4,申请号US201414497644-传众专利搜索

HETEROARYL INHIBITORS OF PDE4

申请公布号：US2015086480(A1)

申请号：US201414497644

申请日期：2014.09.26

申请公布日期：2015.03.26

申请人：

Tetra Discovery Partners, LLC

发明人：D'Amato Emily Catherine;Gurney Mark;Mo Xuesheng;Nugent Richard A.

分类号：C07D307/79;A61K45/06;A61K51/04;A61K31/343

主分类号：C07D307/79

地址：Grand Rapids MI US

摘要：The present invention relates to compounds and methods useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.

主权项：1. A compound of Formula Ior a salt thereof, wherein: X is chosen from O, NH, NR3, and C(R3)2; R1 and R2 are each independently chosen from aryl and heteroaryl, either of which may be optionally substituted; and each R3 is independently chosen from hydrogen and lower alkyl.