Combinations comprising antimuscarinic agents and beta-adrenergic agonists
申请公布号:EP2774622(B1)
申请号:EP20140171380
申请日期:2005.05.31
申请公布日期:2015.03.11
发明人:GRAS ESCARDO, JORDI;LLENAS CALVO, JESÚS;RYDER, HAMISH;ORVIZ DÍAZ, PÍO
分类号:A61K45/06;A61K9/00;A61K31/137;A61K31/167;A61K31/407;A61K31/439;A61K31/4439;A61K31/573;A61K31/58;A61K31/655;A61K45/00;A61P11/00;A61P11/06;A61P11/08
主分类号:A61K45/06
摘要:<p>Combination (I) comprises a phosphodiesterase inhibitor 4 (PDE4) (A) and an antagonist of M3 muscarinic receptors (B) (3(R)-(2-hydroxy-2, 2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo [2.2.2] octane), in the form of a salt having an anion X (anion of a mono or polyvalent acid). An independent claim is also included for a method of treating a patient suffering from or susceptible to a respiratory disease or condition which responds to M3 antagonism comprising simultaneous, concurrent, separate or sequential administration of (I). ACTIVITY : Antiasthmatic; Respiratory-Gen.; Antiinflammatory. MECHANISM OF ACTION : Phosphodiesterase-4 inhibitor; Muscarinic receptors antagonist; Leukotriene-D4 antagonist; Neurokinin-1- receptor antagonist; Epidermal growth factor receptor kinase inhibitor; Beta-2 agonist; p38 Kinase inhibitor.</p>
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