6-O-SUBSTITUTED KETOLIDES HAVING ANTIBACTERIAL ACTIVITY,申请号JP20140190859-传众专利搜索

6-O-SUBSTITUTED KETOLIDES HAVING ANTIBACTERIAL ACTIVITY

申请公布号：JP2015038095(A)

申请号：JP20140190859

申请日期：2014.09.19

申请公布日期：2015.02.26

申请人：

ABBVIE INC

发明人：OR YAT SUN;MA ZHENKUN;CLARK RICHARD F;CHU DANIEL T;PLATTNER JACOB J

分类号：C07H17/08;A61K31/7048;A61P31/04

主分类号：C07H17/08

摘要：<p>PROBLEM TO BE SOLVED: To provide 6-O-substituted ketolides with antibacterial activity, having acid stability and enhanced activity toward gram negative bacteria and macrolide resistant gram positive bacteria.SOLUTION: This invention provides 6-O-substituted erythromycin ketolide derivatives such as formula (II) and compositions comprising the compounds. [Y and Z together form a group X; X is ketone, hydroxyimino or the like; or, one of Y and Z is H and the other is hydrogen, hydroxy or the like; Ris H, hydroxy; Ris H or a hydroxy protective group; R is a substituted methyl group].</p>