HISTONE DEACETYLASE INHIBITORS,申请号HK20090105914-传众专利搜索

HISTONE DEACETYLASE INHIBITORS

申请公布号：HK1126754(A1)

申请号：HK20090105914

申请日期：2009.07.02

申请公布日期：2015.01.16

申请人：

THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE

发明人：JAMES ELLIOT BRADNER;RALPH MAZITSCHEK

分类号：C07C;C07D

主分类号：C07C

摘要：In recognition of the need to develop novel therapeutic agents, the present invention provides novel histone deacetylase inhibitors. These compounds include an ester bond making them sensitive to deactivation by esterases. Therefore, these compounds are particularly useful in the treatment of skin disorders. When the compounds reaches the bloodstream, an esterase or an enzyme with esterase activity cleaves the compound into biologically inactive fragments or fragments with greatly reduced activity Ideally these degradation products exhibit a short serum and/or systemic half-life and are eliminated rapidly. These compounds and pharmaceutical compositions thereof are particularly useful in treating cutaneous T-cell lymphoma, neurofibromatosis, psoriasis, hair loss, skin pigmentation, and dermatitis, for example. The present invention also provides methods for preparing compounds of the invention and intermediates thereto.