医療用化合物あるいは医療用製品を作成するための生体適合性ポリマーの使用方法,申请号JP20110286518-传众专利搜索

医療用化合物あるいは医療用製品を作成するための生体適合性ポリマーの使用方法

申请公布号：JP5646446(B2)

申请号：JP20110286518

申请日期：2011.12.27

申请公布日期：2014.12.24

分类号：A61K31/721;A61K8/73;A61K31/737;A61K31/795;A61P17/04;A61Q19/00

主分类号：A61K31/721

摘要：Using biocompatible polymers (I), containing carboxy and O- or N-sulfonate substituents, in the production of pharmaceutical, dermatological or cosmetic compositions (A) or medical devices (B) for the prevention, alleviation and/or treatment of (or protection of tissue against) discomfort, distress, pruritis, irritation and/or pain, is new. The use of biocompatible polymers of formula (I) in the production of pharmaceutical, dermatological or cosmetic compositions (A) or medical devices (B) for the prevention, alleviation and/or treatment of (or protection of tissue against) discomfort, distress, pruritis, irritation and/or pain. A aX xY y (I) A : monomer; X : RCOOR'; Y : O- or N-sulfonate group attached to A, of formula -ROSO 3R' or -NRSO 3R'; R : linear or branched, saturated or unsaturated aliphatic hydrocarbon chain (optionally containing one or more aromatic rings); R' : H or a cation; a : number of monomer units; x : degree of substitution of the monomers A by X; and y : degree of substitution of the monomers A by Y. ACTIVITY : Dermatological; Antipruritic; Analgesic; Vulnerary; Ophthalmological; Auditory; Antiinflammatory; Antiallergic; Antiulcer; Neuroprotective; Antipsoriatic; Antiasthmatic; Osteopathic; Antiarthritic; Gastrointestinal-Gen. Typically sunburn was treated using a polymer (Ia) consisting of dextran of molecular weight 2 kD which had been carboxymethylated (degree of substitution 0.4-0.5) and O-sulfated (degree of substitution 0.7-1). A solution of (Ia) (100 Microg/ml) in physiological saline containing methyl cellulose (in a amount sufficient to give a thin pasty consistency) was applied to the affected areas. Pain was alleviated within 10-30 minutes, and did not reappear the next day. MECHANISM OF ACTION : None given.