CECROPIN B AND HB-107 DERIVED SHORT BIO-ACTIVE PEPTIDES FOR CELLULAR IMMUNE MODULATION,申请号CA20072673791-传众专利搜索

CECROPIN B AND HB-107 DERIVED SHORT BIO-ACTIVE PEPTIDES FOR CELLULAR IMMUNE MODULATION

申请公布号：CA2673791(C)

申请号：CA20072673791

申请日期：2007.12.27

申请公布日期：2014.11.25

申请人：

HELIX BIOMEDIX INC.

发明人：HARRIS, SCOTT M.;ZHANG, LIJUAN;FALLA, TIMOTHY J.

分类号：C07K14/435;A61K38/00

主分类号：C07K14/435

摘要：Peptides having four to fourteen residues are disclosed that possess biological activity. These peptides constitute short fragments of the peptide HB-107 (SEQ ID NO:1), which itself is a fragment of the antimicrobial protein cecropin B, and exhibit cell stimulatory, migratory and anti-inflammatory properties. As keratinocytes are especially sensitive to these effects, the disclosed peptides comprise a useful agent for the medical treatment of injury to the skin, such as from diabetic ulcers. The peptides also are effective in preventing and reversing skin surface damage resulting from various environmental insults. Importantly, the therapeutic effects of the peptides manifest at concentrations equal to or greater than those of peptide HB-107, and thus represent a less expensive, more versatile means for developing effective therapies. Methods for the production and use of these peptides are also disclosed.