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A pharmaceutical composition for inhibiting metastasis comprising siRNA of BC200 RNA
申请公布号：KR101447227(B1)
申请号：KR20110075419
申请日期：2011.07.28
申请公布日期：2014.10.07
分类号：A61K31/7105;A61K48/00;A61P35/00;C12N15/11
主分类号：A61K31/7105
摘要：PURPOSE: An siRNA which suppresses BC200 RNA activation and a pharmaceutical composition containing the same for suppressing tumor metastasis are provided to inhibit cancer cell migration and metastasis and to effectively treat cancer. CONSTITUTION: An siRNA which suppresses BC200 RNA(sequence number 1) activation has a base sequence of 5'-GUAACUUCCCUCAAAGCAA-3'(sequence number 2) or 5'- UUGCUUUGAGGGAAGUUAC-3'(sequence number 3). The siRNA additionally contains a dTdT base sequence at the 3'-end of the siRNA. A vector contains a polynucleotide which enables transcription of shRNA. The vector transcribes shRNA in a cell and the transcribed shRNA is converted into siRNA by cleavage using RNase III. A pharmaceutical composition for suppressing tumor metastasis contains the vector as an active ingredient. The composition additionally contains a pharmaceutically acceptable carrier. [Reference numerals] (AA) Negative control group siRNA
DOUBLE MOLDING METHOD OF EXPANSION MOLDINGS
PRODUCTION OF COATED METAL STRUCTURE
MANUFACTURING OF FORMED COKE USING CHAMBER OVEN
MANUFACTURE OF ISODEHYDROACETIC ACID ESTER
PHOSPHORIC ACID ESTERS*THEIR MANUFACTURE AND USE
DIBENZ*B*F*AZEPINN10*111EPOXIDE DERIVATIVE
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