(22E)-2-METHYLENE-22-DEHYDRO-1A,24,25-TRIHYDROXY-19-NOR-VITAMIN D3 ANALOGS

申请公布号：CA2897527(A1)

申请号：CA20132897527

申请日期：2013.12.23

申请公布日期：2014.07.31

申请人：

WISCONSIN ALUMNI RESEARCH FOUNDATION

发明人：DELUCA, HECTOR F.;PLUM, LORI A.;BARYCKI, RAFAL;CLAGETT-DAME, MARGARET

分类号：C07C401/00;A61K31/592;A61K31/593;A61P3/02;A61P3/04;A61P5/18;A61P17/00;A61P17/06;A61P19/10;A61P35/00

主分类号：C07C401/00

摘要：Disclosed are (22E)-2-methylene-22-dehydro-1,24,25-trihydroxy-19-nor-vitamin D3 compounds, their biological activities, and various pharmaceutical uses for these compounds. Particularly disclosed are (22E )-(24R)-2-methylene-22-dehydro-1a,24,25-trihydroxy-19-nor-viiamin D3 and (22E)-(24S)-2-methylene-22-dehydro-1a,24,25-triliydroxy-19-nor-vitamin D3, their biological activities, and various pharmaceutical uses for these compounds.

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