MELK REGULATION FOR THE TREATMENT OF BREAST CANCER,申请号WO2014US10724-传众专利搜索

MELK REGULATION FOR THE TREATMENT OF BREAST CANCER

申请公布号：WO2014110163(A2)

申请号：WO2014US10724

申请日期：2014.01.08

申请公布日期：2014.07.17

申请人：

NOVARTIS AG;DANA-FARBER CANCER INSTITUTE, INC.

发明人：HUANG, XIZHONG;ZHAO, JEAN, J.;MIN, JUNXIA;WANG, YUBAO

分类号：C07K14/82

主分类号：C07K14/82

摘要：Methods for inhibiting growth or proliferation of breast cancer cells are provided. The methods include administering to a subject in need thereof in an amount that is effective to inhibit growth or proliferation of the breast cancer cells a MELK inhibitor, wherein the breast cancer cells are estrogen receptor (ER) negative. In some aspects, the methods include administering to a subject in need thereof in an amount that is effective to inhibit growth or proliferation of the breast cancer cells a MELK inhibitor, a FoxM1 inhibitor or a MELK inhibitor and a FoxM1 inhibitor, wherein the breast cancer cells are estrogen receptor (ER) negative. Methods of treatment for breast cancer and methods of identifying patients having cancer that are likely to benefit from treatment with a MELK inhibitor, a FoxM1 inhibitor or a MELK inhibitor and a FoxM1 inhibitor are also provided.