一种萘甲酰胺衍生物及其制备和应用

申请公布号：CN103923004A

申请号：CN201410135803.8

申请日期：2014.04.04

申请公布日期：2014.07.16

申请人：

华侨大学

发明人：王立强;王雪玉;雷严;王红;吴振

分类号：C07D215/233(2006.01)I;A61K31/47(2006.01)I;A61P35/00(2006.01)I

主分类号：C07D215/233(2006.01)I

代理机构：

泉州市文华专利代理有限公司 35205

代理人：陈智海

地址：362000 福建省泉州市丰泽区城东华侨大学

摘要：本发明提供一种萘甲酰胺衍生物及其制备方法和应用，所述萘甲酰胺衍生物为N-(4-甲基苯基)-6-[(7-氯喹啉-4-氧基)酚醚]-2-萘甲酰胺，其可作为蛋白激酶抑制剂和组蛋白去乙酰化酶抑制剂，用于治疗蛋白激酶调节异常所引发的疾病。本发明能够有效治疗蛋白激酶调节异常所引发的疾病，具有生物利用度高、抗癌活性明显和毒性低的优点，且其制备反应成本低，产率高，反应过程简单易控制，适用于工业化生产。

主权项：一种萘甲酰胺衍生物，其特征在于：所述萘甲酰胺衍生物为N‑(4‑甲基苯基)‑6‑[(7‑氯喹啉‑4‑氧基)酚醚]‑2‑萘甲酰胺，其结构式如下式I：<img file="FDA0000487379100000011.GIF" wi="965" he="540" />

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