Methods for promoting wound healing and/or reducing scar formation,申请号US201213343127-传众专利搜索

Methods for promoting wound healing and/or reducing scar formation

申请公布号：US8765673(B2)

申请号：US201213343127

申请日期：2012.01.04

申请公布日期：2014.07.01

申请人：

Arizona Board of Regents

发明人：Brophy Colleen;Panitch Alyssa;Parmiter Catherine;Furnish Elizabeth;Komalavilas Padmini

分类号：A61P17/02;A61P17/00;A61K38/02;A61K38/16

主分类号：A61P17/02

代理机构：

McCarter & English, LLP

代理人：McCarter & English, LLP ;Davis Steven G.

地址：Tempe AZ US

摘要：The present invention provides methods for promoting wound healing and/or reducing scar formation, by administering to an individual in need thereof one or more of the heat shock protein 20-derived polypeptides disclosed herein.

主权项：1. A method for reducing scar formation, comprising administering to an individual in need thereof an amount effective to reduce scar formation of a polypeptide wherein the polypeptide sequence is: B1-X1-A(X2)APLP—X3-B2 wherein X1 is the amino acids of the sequence WLRR (SEQ ID NO: 1); X2 is S and is phosphorylated; X3 is Z1-Z2-Z3, wherein Z1 is G; Z2 is L; Z3 is selected from the group consisting of S, T, and K; and wherein B1 is a transduction domain and B2 is absent or comprises a transduction domain.