Compuestos de anillo espiro-tetracíclico como moduladores de beta-secretasa y métodos de uso,申请号ES20090737222T-传众专利搜索

Compuestos de anillo espiro-tetracíclico como moduladores de beta-secretasa y métodos de uso

申请公布号：ES2459195(T3)

申请号：ES20090737222T

申请日期：2009.09.11

申请公布日期：2014.05.08

申请人：

AMGEN INC.

发明人：WHITE, RYAN;AMEGADZIE, ALBERT;BRYAN, MARIAN C.;CHEN, JIAN J.;CHENG, ALAN C.;DINEEN, THOMAS;EPSTEIN, OLEG;GORE, VIJAY KESHAV;HUA, ZIHAO;HUMAN, JASON B.;HUANG, HONGBING;KREIMAN, CHARLES;LA, DANIEL;LIU, QINGYIAN;MA, VU VAN;MARX, ISAAC;PATEL, VINOD F.;QIAN, WENYUAN;WEISS, MATTHEW;YUAN, CHESTER C.

分类号：C07D498/10;A61K31/424;A61K31/429;A61P25/28;C07D513/10

主分类号：C07D498/10

摘要：The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein A1, A2, A3, A4, A5, A6, T1, T2, W, X, Y and Z of Formula I are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairment, schizophrenia and other central nervous system conditions related to and/or caused by the formation and/or deposition of plaque on the brain. The invention also comprises further embodiments of Formula I, intermediates and processes useful for the preparation of compounds of Formula I.