Production of glycoproteins with reduced O-glycosylation,申请号AU20120203729-传众专利搜索

Production of glycoproteins with reduced O-glycosylation

申请公布号：AU2012203729(B2)

申请号：AU20120203729

申请日期：2012.06.22

申请公布日期：2014.01.30

申请人：

GLYCOFI, INC

发明人：COOK, JAMES W.;KETT, WARREN;BOBROWICZ, PIOTR

分类号：C12N1/15;A61K38/00;C12N1/16;C12N1/19

主分类号：C12N1/15

摘要：PRODUCTION OF GLYCOPROTEINS WITH REDUCED 0 GLYCOSYLATION Abstract A method is described for producing protein compositions having reduced amounts of 0- linked glycosylation. The method includes producing the protein in cells cultured in the presence of an inhibitor of Pmt-mediated 0-linked glycosylation and/or in the presence of one or more a-1,2 mannosidases.