Bi- and monospecific, asymmetric antibodies and methods of generating the same,申请号EP20120716657-传众专利搜索

Bi- and monospecific, asymmetric antibodies and methods of generating the same

申请公布号：EP2686348(A1)

申请号：EP20120716657

申请日期：2012.03.15

申请公布日期：2014.01.22

申请人：

RAMOT AT TEL-AVIV UNIVERSITY LTD.

发明人：BENHAR, ITAI;VAKS, LILACH

分类号：C07K16/28;A61K39/00;C07K16/00;C07K16/32

主分类号：C07K16/28

摘要：An antibody is provided. The antibody comprises an Fc region and a Fab region, wherein: (i) the Fc region comprises two non-identical heavy chains, wherein at least one of the two non-identical heavy chains comprises an amino acid modification so as to form complementation between the two non-identical heavy chains thereby increasing the probability of forming heterodimers of the non-identical heavy chains and decreasing the probability of forming homodimers of identical heavy chains; and (ii) the Fab region comprises a first covalent link between a first heavy chain and a first light chain of the Fab region and a second covalent link between a second heavy chain and a second light chain of said Fab region, wherein a position of the first covalent link relative to the first heavy chain is different to a position of the second covalent link relative to the second heavy chain.