SAXAGLIPTIN SOLID DISPERSION

申请公布号：WO2013171766(A3)

申请号：WO2013IN00311

申请日期：2013.05.13

申请公布日期：2014.01.03

申请人：

HETERO RESEARCH FOUNDATION;PARTHASARADHI REDDY, BANDI;RATHNAKAR REDDY, KURA;MURALIDHARA REDDY, DASARI;SUBASH CHANDER REDDY, KESIREDDY;VAMSI KRISHNA, BANDI

发明人：PARTHASARADHI REDDY, BANDI;RATHNAKAR REDDY, KURA;MURALIDHARA REDDY, DASARI;SUBASH CHANDER REDDY, KESIREDDY;VAMSI KRISHNA, BANDI

分类号：A61K31/403

主分类号：A61K31/403

摘要：The present invention provides a novel amorphous solid dispersion of saxagliptin in combination with a pharmaceutically acceptable carrier, process for its preparation and pharmaceutical compositions comprising it. In a preferred embodiment, the process for the preparation of amorphous solid dispersion of saxagliptin in combination with a pharmaceutically acceptable carrier comprises: preparing a solution comprising a mixture of saxagliptin and one or more pharmaceutically acceptable carriers selected from copovidone, ethyl cellulose, hydroxypropyl methylcellulose, polyethylene glycol or soluplus in a solvent; and removing the solvent to obtain amorphous solid dispersion of saxagliptin in combination with a pharmaceutically acceptable carrier.

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