Enzymatic synthesis of amino acid and peptide c-terminal amides,申请号EP20120157576-传众专利搜索

Enzymatic synthesis of amino acid and peptide c-terminal amides

申请公布号：EP2634258(A1)

申请号：EP20120157576

申请日期：2012.02.29

申请公布日期：2013.09.04

申请人：

ENZYPEP B.V.

发明人：NUIJENS, TIMO;QUAEDFLIEG, PETER JAN LEONARD MARIO

分类号：C12P21/02;C12N9/48

主分类号：C12P21/02

摘要：Method for enzymatically synthesising an amino acid or peptide C- terminal amide, from the corresponding N-protected amino acid ammonium salt or optionally N-protected peptide C -terminal carboxylic acid ammonium salt, by contacting said N-protected amino acid ammonium salt or optionally N-protected peptide C-terminal carboxylic acid ammonium salt with a serine endopeptidase. in an organic solvent or an organic solvent mixture containing 1 vol% or less water.