Vaccine antigens that direct immunity to conserved epitopes,申请号AU20110344126-传众专利搜索

Vaccine antigens that direct immunity to conserved epitopes

申请公布号：AU2011344126(A1)

申请号：AU20110344126

申请日期：2011.12.12

申请公布日期：2013.07.11

申请人：

UNIVERSITY OF UTAH RESEARCH FOUNDATION

发明人：BOCK, SUSAN C.

分类号：G01N33/48;A61K39/00

主分类号：G01N33/48

摘要：A method of identification and elimination of immunodominant epitopes to elicit a response to secondary epitopes, especially conserved structures, is described, and applied to influenza haemagglutinin (HA). Identification of the primary epitopes in (HA), and replacement of amino acids having high LODrps with corresponding low LODrps amino acids produces an HA molecule which induces antibody responses to conserved HA residues. Modified HA molecules induce a broadly neutralizing vaccine.