METHODS OF TREATING AUTOIMMUNE DISEASES

申请公布号：EP2012814(B1)

申请号：EP20070760469

申请日期：2007.04.11

申请公布日期：2013.05.22

申请人：

GENZYME CORPORATION

发明人：KAPLAN, JOHANNE;MCPHERSON, JOHN, M.

分类号：A61K38/18;A61K39/395;A61P37/00;C07K16/28

主分类号：A61K38/18

摘要：Methods for treating patients with autoimmune diseases are disclosed, The methods of the application include first depleting circulating lymphocytes in the mammal, e.g., by administering anti-thymocyte antibody, and then, during the course of repopulation, administering to the mammal a therapeutically effective amount of latent TGF-² and/or another agent that promotes expansion of regulatory T cells. In certain aspects, the disclosed process results in improved kidney function and survival rates.

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