与谷氨酰-脯氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现

申请公布号：CN103096909A

申请号：CN201180031549.1

申请日期：2011.05.04

申请公布日期：2013.05.08

申请人：

ATYR 医药公司;盘古生物制药有限公司

发明人：莱斯利·安·格林尼;凯尔·P·基昂格;洪非;阿兰·P·瓦瑟洛特;罗咏诗;杰弗里·D·沃特金斯;约翰·D·门德莱恩;谢丽尔·L·奎恩

分类号：A61K38/08(2006.01)I

主分类号：A61K38/08(2006.01)I

代理机构：

北京英赛嘉华知识产权代理有限责任公司 11204

代理人：王达佐;洪欣

地址：美国加利福尼亚州

摘要：本文提供了包含氨酰-tRNA合成酶的新鉴定的蛋白片段的组合物、编码所述蛋白片段的多核苷酸及其互补物、相关剂、及其在诊断、药物发现、研究和治疗应用中的使用方法。

主权项：一种组合物，包含至少35个氨基酸的分离的氨酰‑tRNA合成酶(AARS)蛋白片段，所述蛋白片段包含表1‑3、或表4‑6、或表7‑9任一个中所列的氨基酸序列，其中所述蛋白片段具有至少约5mg/mL的溶解度，并且其中所述组合物以蛋白基计具有至少约95%的纯度，小于约10EU内毒素/mg蛋白，并且基本上没有血清。

SERVICE PARTITION VIRTUALIZATION SYSTEM AND METHOD HAVING A SECURE APPLICATION

COMPARE AND DELAY INSTRUCTIONS

CHECKSUM ADDER

IMAGE PROCESSING APPARATUS

IMAGE FORMING APPARATUS HAVING TONER SAVING FUNCTION AND METHOD FOR PRINTING

IMAGE PROCESSING APPARATUS, CONTROL METHOD THEREOF, AND STORAGE MEDIUM

IMAGE FORMING APPARATUS, METHOD FOR CONTROLLING THE SAME, AND COMPUTER-READABLE STORAGE MEDIUM

MEMORY INTERFACE SUPPORTING BOTH ECC AND PER-BYTE DATA MASKING

COMPUTER SYSTEM, STORAGE MANAGEMENT COMPUTER, AND STORAGE MANAGEMENT METHOD

MIGRATING WORKLOADS ACROSS HOST COMPUTING SYSTEMS BASED ON CACHE CONTENT USAGE CHARACTERISTICS

LIFECYCLE MANAGEMENT OF SOLID STATE MEMORY ADAPTORS

FLEXIBLE STORAGE BLOCK FOR A SOLID STATE DRIVE (SSD)-BASED FILE SYSTEM

METHOD FOR CONTROLLING INFORMATION APPARATUS AND COMPUTER-READABLE RECORDING MEDIUM

OPTIMIZED PRESENTATION OF MULTIMEDIA CONTENT

METHOD AND APPARATUS FOR GESTURE OPERATION ON ADDRESS BAR AND TOUCH SCREEN TERMINAL

Touch Screen Instrument Panel

TOUCH PANEL HAVING UNEVENLY DISTRIBUTED ELECTRIC FIELD LINES AND CONTROLLING METHOD THEREOF

ELECTRONIC DEVICE HAVING DISPLAY AND SURROUNDING TOUCH SENSITITVE BEZEL FOR USER INTERFACE AND CONTROL

CORRECTION APPARATUS AND CORRECTION METHOD FOR SELF-CAPACITIVE TOUCH PANEL

ELECTRONIC DEVICE HAVING OPTICAL INDEXING MODULE