PEPTIDI E LORO DERIVATI CHE INIBISCONO IL RILASCIO EXTRACELLULARE DELLA PROTEINA TAT DI HIV-1 E LA REPLICAZIONE DI HIV-1.,申请号IT2009RM00650-传众专利搜索

PEPTIDI E LORO DERIVATI CHE INIBISCONO IL RILASCIO EXTRACELLULARE DELLA PROTEINA TAT DI HIV-1 E LA REPLICAZIONE DI HIV-1.

申请公布号：IT1397569(B1)

申请号：IT2009RM00650

申请日期：2009.12.10

申请公布日期：2013.01.16

申请人：

INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY (ICGEB);SCUOLA NORMALE SUPERIORE DI PISA

发明人：AGOSTINI SILVIA;GIACCA MAURO

分类号：C12N9/14

主分类号：C12N9/14

摘要：<p>A protein comprising a single or a combination of three intracytoplasmatic peptide stretches of the C- terminal domain of the Na+, K+-ATPase alpha sub-unit is herein disclosed, all said peptide stretches binding HIV-1 Tat protein. Said protein is the fusion of said three stretches, corresponding to the 824-843, 939-951 and 1007-1023 regions of said domain and have the sequence NH2 - YEQAESDIMKRQPRNPKTDK- COOH, NH2 - TRRNSVFQQGMKN- COOH, NH2 - LIIRRRPGGWVEKETYY- COOH. The invention also discloses a mammal expression vector expressing said protein and the corresponding DNA. The use of said substance is also disclosed for inhibiting HIV-1 Tat protein transactivation, inhibiting HIV-1 replication and treating HIV-1 infection and related diseases.</p>