pH sensitive block copolymer and polymeric micelle using the same,申请号US20050573858-传众专利搜索

pH sensitive block copolymer and polymeric micelle using the same

申请公布号：US8318204(B2)

申请号：US20050573858

申请日期：2005.12.27

申请公布日期：2012.11.27

申请人：

LEE DOO SUNG;KIM MIN SANG;SUNGKYUNKWAN UNIVERSITY FOUNDATION FOR CORPORATE COLLABORATION

发明人：LEE DOO SUNG;KIM MIN SANG

分类号：A61K9/14;A61K47/00

主分类号：A61K9/14

摘要：Disclosed is a pH-sensitive block copolymer obtained by copolymerization of: (a) a polyethylene glycol compound (A); and (b) at least one poly(amino acid) compound selected from the group consisting of a poly(&bgr;-amino ester) and poly(amido amine) or a copolymer thereof (B). A method for preparing the same block copolymer, and a polymer micelle type drug composition comprising the pH-sensitive block copolymer and a physiologically active substance that can be encapsulated with the block copolymer are also disclosed. The pH-sensitive block copolymer is obtained by polymerization of a hydrophilic polyethylene glycol compound with a pH-sensitive biodegradable poly(amino acid) compound. Therefore, the pH-sensitive block copolymer can form a micelle structure due to its amphiphilicity and ionization characteristics depending on pH variations, and thus can be used as drug carrier for target-directed drug delivery depending on pH variations in the body.