ANHYDROUS POLYMORPHIC FORM B OF BOSENTAN AND USES THEREOF

申请公布号：NZ586900(A)

申请号：NZ20090586900

申请日期：2009.01.02

申请公布日期：2012.10.26

申请人：

CIPLA LIMITED

发明人：RAO, DHARMARAJ, RAMACHANDRA;KANKAN, RAJENDRA, NARAYANRAO;PHULL, MANJINDER, SINGH;SAWANT, ASHWINI, AMOL

分类号：C07D239/69;A61K31/506;A61P9/12

主分类号：C07D239/69

摘要：<p>Disclosed is anhydrous bosentan polymorphic Form B, characterised by having an XRPD pattern comprising peaks at 9.6, 16.1, 17.1, 18.4 and 5 21.8 °2q + 0.2°2q. Further disclosed is a process for preparing the above anhydrous polymorphic form which comprises: adding bosentan to a mixture of ethyl acetate and heptane, heating the mixture to the reflux temperature of the solvent mixture, cooling the mixture to a temperature ranging from 20°C to 30°C, and drying the resulting solid at a temperature above 60°C to obtain anhydrous bosentan Form B.</p>

Drive arrangement for a sliding panel of an automobile, in particular a door's pane raiser.

Temporary store for washing machine water - has valve mechanism in insulated tank diverting to store or waste

ANORDNING VED STYRINGSSPERRENDE, TYVERIHINDRENDE LAAS FOR MOTORKJOERETOEYER

Multicolored yarn and its manufacturing method.

INNRETNING TIL MONTERING OG DEMONTERING AV VEIVAKSELLAGERDEKSLET I EN FORBRENNINGSMOTOR

A HYDRAULIC DRIVER FOR A SHUTTLE.

DOG'S SANITARY BOX.

EXPANDABLE VEHICLE.

PROCESS FOR MAKING RAISED RELIEF MOTIVES ONTO DRAWINGS PRINTED ON FLEXIBLE THERMOPLASTIC MATERIAL.

ATTACHMENT FOR REMOTE CONTROL OF A KEYBOARD.

NACHSPANNFREIE SPANNVORRICHTUNG FUER SPANNBARE SIEBBOEDEN

Filter for filtering greasy particles from a gaseous stream, particularly polluted kitchen air, and expelling duct therefor.

Electro-acoustic transducer with a membrane having a piezoelectric layer.

Drive and/or brake control system for vehicles with DC series wound commutator motors.

Process for the preparation of cis-2.6-dimethylmorpholine.

Seal for coaxial rotating parts.

Benzofurane derivatives, process for their preparation and therapeutic composition containing them.

BAR GRAPH DRIVE CIRCUIT

MASS MEASURING UNIT FOR OBJECT IN CLOSED VESSEL

DUST CONCENTRATION METER