UNSYMMETRICAL PYRROLOBENZODIAZEPINE-DIMERS FOR TREATMENT OF PROLIFERATIVE DISEASES

申请公布号：NZ591425(A)

申请号：NZ20090591425

申请日期：2009.10.16

申请公布日期：2012.09.28

申请人：

SPIROGEN LIMITED

发明人：HOWARD, PHILIP, WILSON;GREGSON, STEPHEN, JOHN;MASTERSON, LUKE

分类号：C07D487/04;A61K31/5517;A61P35/00

主分类号：C07D487/04

摘要：Disclosed herein are un symmetrical pyrrolobenzodiazepine compounds for formula I, wherein the substituents are as defined within the specification, processes for their preparation, compositions comprising said compounds and uses thereof. Said compounds are useful in the treatment of a proliferative disease. Particularly preferred is the compound (S)-2-(4-aminophenyl)-7-methoxy-8-(3-((S)-7-methoxy-2-(4-methoxyphenyl)-5-oxo-5,11a-dihydro-1 H-pyrrolo[2,1-c][1,4]benzodiazepine-8-yloxy)propoxy)-1H-pyrorolo[2,1-c][1 ,4]benzodiazepine-5(11a H)one.

PRODUCTION OF INORGANIC FIBER FELT

HYDROTREATMENT PROCESS EMPLOYING CATALYST WITH SPECIFIED PORE SIZE DISTRIBUTION

STACKING PLASTIC BUFFER WARE

DEVICE FOR THREATENING BIRD

INTERNAL COMBUSTION ENGINE WITH OIL FILTER

SURFACE COVERING SILICON NITRIDE GROUP CERAMICS CUTTING TOOL

TETRAZOLE EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS

FLEXIBLE AND PRESSURE PERMEABLE THERMAL PROTECTION DEVICE

DRUM WITH SELF SUPPORTING LINER

BRAKE CONTROL DEVICE FOR VEHICLE

PROTECTIVE SHEET DEVICE FOR VEHICLE

DIFFERENTIAL GEAR MOUNT STRUCTURE OF VEHICLE

PNEUMATIC TIRE

PNEUMATIC TIRE

STORAGE LIFESTYLE CHECK SYSTEM

PRINTER

IMAGE PROCESSING DEVICE

SEAT DEVICE FOR VEHICLE

SHIFT LEVER DEVICE

VAPORIZED FUEL COLLECTING DEVICE FOR ENGINE